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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HEATR1
All Species:
24.55
Human Site:
S516
Identified Species:
41.54
UniProt:
Q9H583
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.23
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H583
NP_060542.4
2144
242370
S516
S
K
E
G
V
D
E
S
F
I
K
E
A
V
L
Chimpanzee
Pan troglodytes
XP_001156974
2144
242420
S516
S
K
E
G
V
D
E
S
F
I
K
E
A
V
L
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536334
2141
242568
S516
S
E
E
N
V
D
E
S
F
I
K
E
A
V
L
Cat
Felis silvestris
Mouse
Mus musculus
NP_659084
2143
242053
T516
S
K
E
G
I
D
E
T
F
I
K
E
A
I
L
Rat
Rattus norvegicus
NP_001101888
2143
241191
T516
S
K
E
G
I
D
E
T
F
I
K
E
A
I
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422958
2155
244590
S516
S
K
E
G
F
D
Q
S
F
I
E
E
A
I
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q7SY48
2159
242032
A514
E
H
N
S
F
D
E
A
F
L
K
D
A
L
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VM75
2096
237201
K525
K
K
R
E
R
S
V
K
L
L
Q
E
C
L
P
Honey Bee
Apis mellifera
XP_393800
2028
231830
N498
S
F
R
E
M
M
T
N
T
I
Q
S
R
F
S
Nematode Worm
Caenorhab. elegans
Q23495
1650
185210
S187
I
A
R
A
T
L
S
S
K
H
S
I
I
T
C
Sea Urchin
Strong. purpuratus
XP_794611
1635
181917
R172
K
P
G
V
S
L
S
R
L
S
L
V
T
H
C
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9C8Z4
2001
224001
S499
N
G
V
L
K
D
D
S
S
K
A
E
N
L
V
Baker's Yeast
Sacchar. cerevisiae
P42945
1769
200063
L306
I
C
K
L
F
Q
T
L
K
G
Q
G
N
V
D
Red Bread Mold
Neurospora crassa
Q7RZM8
1788
196873
R325
S
A
K
Q
L
S
A
R
V
T
K
A
L
L
K
Conservation
Percent
Protein Identity:
100
99.5
N.A.
89.7
N.A.
83.8
84.9
N.A.
N.A.
65.5
N.A.
54.5
N.A.
28.6
30.5
21.1
24.4
Protein Similarity:
100
99.8
N.A.
95
N.A.
92.1
92.7
N.A.
N.A.
80.5
N.A.
73
N.A.
49.4
50.8
38.9
43.2
P-Site Identity:
100
100
N.A.
86.6
N.A.
80
80
N.A.
N.A.
73.3
N.A.
40
N.A.
13.3
13.3
6.6
0
P-Site Similarity:
100
100
N.A.
93.3
N.A.
100
100
N.A.
N.A.
93.3
N.A.
66.6
N.A.
33.3
33.3
6.6
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.4
21.2
23
Protein Similarity:
N.A.
N.A.
N.A.
43.4
40.2
42.2
P-Site Identity:
N.A.
N.A.
N.A.
20
6.6
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
20
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
15
0
8
0
0
8
8
0
0
8
8
50
0
0
% A
% Cys:
0
8
0
0
0
0
0
0
0
0
0
0
8
0
15
% C
% Asp:
0
0
0
0
0
58
8
0
0
0
0
8
0
0
8
% D
% Glu:
8
8
43
15
0
0
43
0
0
0
8
58
0
0
0
% E
% Phe:
0
8
0
0
22
0
0
0
50
0
0
0
0
8
0
% F
% Gly:
0
8
8
36
0
0
0
0
0
8
0
8
0
0
0
% G
% His:
0
8
0
0
0
0
0
0
0
8
0
0
0
8
0
% H
% Ile:
15
0
0
0
15
0
0
0
0
50
0
8
8
22
0
% I
% Lys:
15
43
15
0
8
0
0
8
15
8
50
0
0
0
8
% K
% Leu:
0
0
0
15
8
15
0
8
15
15
8
0
8
29
50
% L
% Met:
0
0
0
0
8
8
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
8
8
0
0
0
8
0
0
0
0
15
0
0
% N
% Pro:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
8
% P
% Gln:
0
0
0
8
0
8
8
0
0
0
22
0
0
0
0
% Q
% Arg:
0
0
22
0
8
0
0
15
0
0
0
0
8
0
0
% R
% Ser:
58
0
0
8
8
15
15
43
8
8
8
8
0
0
8
% S
% Thr:
0
0
0
0
8
0
15
15
8
8
0
0
8
8
0
% T
% Val:
0
0
8
8
22
0
8
0
8
0
0
8
0
29
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _